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Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Frontiers of Medicine 2010, Volume 4, Issue 4,   Pages 356-362 doi: 10.1007/s11684-010-0220-5

Abstract: Acute myeloid leukemia (AML) is a very heterogeneous neoplasm of the hematopoietic stem cell.

Keywords： acute myeloid leukemia     mutations     risk stratification    

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Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2020, Volume 14, Issue 6,   Pages 689-700 doi: 10.1007/s11684-020-0759-8

Abstract: The cure rate of childhood acute lymphoblastic leukemia (ALL) has exceeded 90% in some contemporary clinical

Keywords： acute lymphoblastic leukemia     molecular therapeutics     targeted therapy     tyrosine kinase inhibitors     immunotherapy    

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Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Frontiers of Medicine 2015, Volume 9, Issue 1,   Pages 1-9 doi: 10.1007/s11684-015-0381-3

Abstract:

With the cure rate of childhood acute lymphoblastic leukemia (ALL) approaching 90%, further improvement

Keywords： pharmacogenomics     acute lymphoblastic leukemia     genomics     pharmacogenetics    

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expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute

Frontiers of Medicine 2022, Volume 16, Issue 4,   Pages 627-636 doi: 10.1007/s11684-020-0815-4

Abstract: Its dysfunction, caused by either fusions or mutations, is frequently reported in acute myeloid leukemia

Keywords： RUNX1     gene mutation     acute myeloid leukemia     transcriptional repression     DNA methylation    

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Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Frontiers of Medicine 2018, Volume 12, Issue 3,   Pages 307-318 doi: 10.1007/s11684-017-0547-2

Abstract:

Acute ischemic stroke (AIS), as the third leading cause of death worldwide, is characterized by itsThe neuroprotective effects of extract (GBE) against several cerebral diseases have been reported incortical capillary endothelial cell-astrocyte-neuron network model, we investigated the neuroprotective effectsResults demonstrated the preventive effects of GBE on neuronal cell death and enhancement of the function

Keywords： acute ischemic stroke     Ginkgo bilobaextract     Ginkgolide B     network model     neuroprotection    

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Two-dimensional numerical and eco-toxicological modeling of chemical spills

Suiliang HUANG, Yafei JIA, Sam S. Y. WANG

Frontiers of Environmental Science & Engineering 2009, Volume 3, Issue 2,   Pages 178-185 doi: 10.1007/s11783-009-0020-9

Abstract: The effects of chemical spills on aquatic non-target organisms were evaluated in this study.Theoretical analysis and simulated results indicated that this model is capable of reasonably predicting the acuteeffects of chemical spills on aquatic ecosystems or organism killings.

Keywords： chemical spills     acute effects     aquatic ecosystem     eco-toxicological modeling    

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Current treatment strategy of acute promyelocytic leukemia

Jianqing Mi

Frontiers of Medicine 2011, Volume 5, Issue 4,   Pages 341-347 doi: 10.1007/s11684-011-0169-z

Abstract: Acute promyelocytic leukemia (APL) is a unique subtype of acute myeloid leukemia (AML).disease, including the initial approaches to newly diagnosed patients, prevention, and treatment of side effects

Keywords： acute promyelocytic leukemia     all-trans retinoic acid     arsenic trioxide    

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Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Frontiers of Medicine 2022, Volume 16, Issue 6,   Pages 909-918 doi: 10.1007/s11684-021-0890-1

Abstract: In patients with acute promyelocytic leukemia (APL), intracranial hemorrhage (ICH), if not identified

Keywords： acute promyelocytic leukemia     intracranial hemorrhage     cytokines     biomarker    

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Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Frontiers of Medicine 2017, Volume 11, Issue 3,   Pages 393-402 doi: 10.1007/s11684-017-0532-9

Abstract:

The risk factors, especially laboratory indicators, of prognosis after acute kidney injury (AKI) remain

Keywords： acute kidney injury     risk factors     prognosis    

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Treatment of severe acute pancreatitis through retroperitoneal laparoscopic drainage

Chun Tang, Baolin Wang, Bing Xie, Hongming Liu, Ping Chen

Frontiers of Medicine 2011, Volume 5, Issue 3,   Pages 302-305 doi: 10.1007/s11684-011-0145-7

Abstract: A treatment method based on drainage via retroperitoneal laparoscopy was adopted for 15 severe acute

Keywords： severe acute pancreatitis (SAP)     laparoscope     retroperitoneal drainage     treatment    

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Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Frontiers of Medicine 2022, Volume 16, Issue 3,   Pages 442-458 doi: 10.1007/s11684-021-0877-y

Abstract: T-cell acute lymphoblastic leukemia (T-ALL) is one of the most dangerous hematological malignancies,

Keywords： T-cell acute lymphoblastic leukemia     HDAC inhibitor     chidamide     NOTCH1     MYC     ubiquitination    

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Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese

Frontiers of Medicine 2023, Volume 17, Issue 3,   Pages 518-526 doi: 10.1007/s11684-022-0958-6

Abstract: Venous thromboembolism (VTE) is a complication in children with acute lymphoblastic leukemia (ALL).

Keywords： acute lymphoblastic leukemia     child     venous thromboembolism     epidemiology     clinical characteristic     risk    

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Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Frontiers of Medicine 2012, Volume 6, Issue 4,   Pages 416-420 doi: 10.1007/s11684-012-0224-4

Abstract:

Acute lymphoblastic leukemia includes T-cell acute lymphoblastic leukemia (T-ALL) and B-cell acuteThis novel subtype of T-ALL was called early T-cell precursor acute lymphoblastic leukemia (ETP-ALL).Our findings demonstrate that early T-cell precursor leukemia is a very high-risk subtype of acute lymphoblastic

Keywords： acute lymphoblastic leukemia     early T precursor     prognosis    

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Artificial Intelligence Cracks a 50-Year-Old Grand Challenge in Biology

Sean O´Neill

Engineering 2021, Volume 7, Issue 6,   Pages 706-708 doi: 10.1016/j.eng.2021.04.003

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Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary

Tao Li, Nanfu Luo, Lei Du, Jin Liu, Lina Gong, Jing Zhou

Frontiers of Medicine 2012, Volume 6, Issue 3,   Pages 296-301 doi: 10.1007/s11684-012-0219-1

Abstract: improved the development of modern cardiac surgery, many factors during CPB have been reported to induce acute

Keywords： tumor necrosis factor-α     cardiopulmonary bypass     inflammation     acute respiratory distress syndrome    

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Title Author Date Type Operation

Molecular pathogenesis of acute myeloid leukemia: A diverse disease with new perspectives

Felicitas THOL, Arnold GANSER

Journal Article

Precision medicine in acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

Genomic and pharmacogenetic studies of childhood acute lymphoblastic leukemia

Ching-Hon Pui

Journal Article

expression pattern of mutations coordinated by target repression and promoter hypermethylation in acute

Journal Article

Neuroprotective effects of Ginkgo biloba extract and Ginkgolide B against oxygen–glucose deprivation/

Xiaohan Yang, Tiezheng Zheng, Hao Hong, Nan Cai, Xiaofeng Zhou, Changkai Sun, Liying Wu, Shuhong Liu, Yongqi Zhao, Lingling Zhu, Ming Fan, Xuezhong Zhou, Fengxie Jin

Journal Article

Two-dimensional numerical and eco-toxicological modeling of chemical spills

Suiliang HUANG, Yafei JIA, Sam S. Y. WANG

Journal Article

Current treatment strategy of acute promyelocytic leukemia

Jianqing Mi

Journal Article

Predictive values of plasma TNFα and IL-8 for intracranial hemorrhage in patients with acute promyelocytic

Journal Article

Risk factors of prognosis after acute kidney injury in hospitalized patients

Sasa Nie, Zhe Feng, Lihua Xia, Jiuxu Bai, Fenglin Xiao, Jian Liu, Li Tang, Xiangmei Chen

Journal Article

Treatment of severe acute pancreatitis through retroperitoneal laparoscopic drainage

Chun Tang, Baolin Wang, Bing Xie, Hongming Liu, Ping Chen

Journal Article

Chidamide inhibits the NOTCH1-MYC signaling axis in T-cell acute lymphoblastic leukemia

Journal Article

Venous thromboembolism in children with acute lymphoblastic leukemia in China: a report from the Chinese

Journal Article

Early T-cell precursor leukemia: a subtype of high risk childhood acute lymphoblastic leukemia

Meilin Ma, Xiang Wang, Jingyan Tang, Huiliang Xue, Jing Chen, Ci Pan, Hua Jiang, Shuhong Shen

Journal Article

Artificial Intelligence Cracks a 50-Year-Old Grand Challenge in Biology

Sean O´Neill

Journal Article

Early and marked up-regulation of TNF-α in acute respiratory distress syndrome after cardiopulmonary

Tao Li, Nanfu Luo, Lei Du, Jin Liu, Lina Gong, Jing Zhou

Journal Article